Biblioteca de investigación

Referencias

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   Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS-1) — Rosenstock J, Wysham C, Frías JP, et al.

   The Lancet. 2021. RCT — Source

2. [2]

   Tirzepatide versus semaglutide once weekly in patients with type 2 diabetes (SURPASS-2) — Frías JP, Davies MJ, Rosenstock J, et al.

   New England Journal of Medicine. 2021. RCT — Source

3. [3]

   Tirzepatide once weekly for the treatment of obesity (SURMOUNT-1) — Jastreboff AM, Aronne LJ, Ahmad NN, et al.

   New England Journal of Medicine. 2022. RCT — Source

4. [4]

   Continued treatment with tirzepatide for maintenance of weight reduction in adults with obesity (SURMOUNT-4) — Aronne LJ, Sattar N, Horn DB, et al.

   JAMA. 2024. RCT — Source

5. [5]

   FDA Prescribing Information — MOUNJARO (tirzepatide) injection — U.S. Food and Drug Administration

   2022. guideline — Source

6. [6]

   FDA Prescribing Information — ZEPBOUND (tirzepatide) injection — U.S. Food and Drug Administration

   2023. guideline — Source

7. [7]

   Mounjaro (tirzepatide) — European Public Assessment Report (EPAR) — European Medicines Agency

   2022. guideline — Source

8. [8]

   Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2) — Garvey WT, Frías JP, Jastreboff AM, et al.

   The Lancet. 2023. RCT — Source

9. [9]

   Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist — Willard FS, Douros JD, Gabe MBN, et al.

   JCI Insight. 2020. preclinical — Source

10. [10]

    Once-Weekly Semaglutide in Adults with Overweight or Obesity (STEP 1) — Wilding JPH, Batterham RL, Calanna S, et al.

    New England Journal of Medicine. 2021. RCT — Source

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    Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity: The STEP 4 Randomized Clinical Trial — Rubino D, Abrahamsson N, Davies M, et al.

    JAMA. 2021. RCT — Source

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    Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial — Garvey WT, Batterham RL, Bhatta M, et al.

    Nature Medicine. 2022. RCT — Source

13. [13]

    Effect of Weekly Subcutaneous Semaglutide vs Daily Liraglutide on Body Weight in Adults With Overweight or Obesity Without Diabetes: The STEP 8 Randomized Clinical Trial — Rubino DM, Greenway FL, Khalid U, et al.

    JAMA. 2022. RCT — Source

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    Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes (SUSTAIN-6) — Marso SP, Bain SC, Consoli A, et al.

    New England Journal of Medicine. 2016. RCT — Source

15. [15]

    Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes (SELECT) — Lincoff AM, Brown-Frandsen K, Colhoun HM, et al.

    New England Journal of Medicine. 2023. RCT — Source

16. [16]

    Effect of Additional Oral Semaglutide vs Sitagliptin on Glycated Hemoglobin in Adults With Type 2 Diabetes Uncontrolled With Metformin Alone or With Sulfonylurea: The PIONEER 3 Randomized Clinical Trial — Rosenstock J, Allison D, Birkenfeld AL, et al.

    JAMA. 2019. RCT — Source

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    Semaglutide in Patients with Heart Failure with Preserved Ejection Fraction and Obesity (STEP-HFpEF) — Kosiborod MN, Abildstrøm SZ, Borlaug BA, et al.

    New England Journal of Medicine. 2023. RCT — Source

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    Effects of Semaglutide on Chronic Kidney Disease in Patients with Type 2 Diabetes (FLOW) — Perkovic V, Tuttle KR, Rossing P, et al.

    New England Journal of Medicine. 2024. RCT — Source

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    FDA Prescribing Information — OZEMPIC (semaglutide) injection — U.S. Food and Drug Administration

    2017. guideline — Source

20. [20]

    FDA Prescribing Information — WEGOVY (semaglutide) injection — U.S. Food and Drug Administration

    2021. guideline — Source

21. [21]

    FDA Prescribing Information — RYBELSUS (semaglutide) tablets — U.S. Food and Drug Administration

    2019. guideline — Source

22. [22]

    Ozempic (semaglutide) — European Public Assessment Report (EPAR) — European Medicines Agency

    2018. guideline — Source

23. [23]

    Wegovy (semaglutide) — European Public Assessment Report (EPAR) — European Medicines Agency

    2022. guideline — Source

24. [24]

    Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide — Lau J, Bloch P, Schäffer L, et al.

    Journal of Medicinal Chemistry. 2015. preclinical — Source

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    Effects of tesamorelin (TH9507), a growth hormone–releasing factor analog, in HIV-infected patients with excess abdominal fat — Falutz J, Allas S, Blot K, et al.

    New England Journal of Medicine. 2007. RCT — Source

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    Long-term safety and effects of tesamorelin, a growth hormone-releasing factor analogue, in HIV patients with abdominal fat accumulation — Falutz J, Potvin D, Mamputu JC, et al.

    AIDS. 2010. RCT — Source

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    Effects of tesamorelin on visceral fat and liver fat in HIV-infected patients with abdominal fat accumulation: a randomized clinical trial — Stanley TL, Feldpausch MN, Oh J, et al.

    JAMA. 2014. RCT — Source

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    Effects of tesamorelin on non-alcoholic fatty liver disease in HIV: a randomised, double-blind, multicentre trial — Stanley TL, Fourman LT, Feldpausch MN, et al.

    The Lancet HIV. 2019. RCT — Source

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    FDA Prescribing Information — EGRIFTA / EGRIFTA SV (tesamorelin) for injection — U.S. Food and Drug Administration

    2010. guideline — Source

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    Growth hormone-releasing hormone (GHRH)(1-29)NH2 for treatment of GH deficiency in adults: a randomized, double-blind, placebo-controlled trial — Walker RF, Codd EE, Barone FC, et al.

    Journal of Clinical Endocrinology & Metabolism. 1994. RCT — Source

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    Once daily subcutaneous growth hormone-releasing hormone therapy accelerates growth in growth hormone-deficient children during the first year of therapy — Thorner MO, Rochiccioli P, Colle M, et al.

    Journal of Clinical Endocrinology & Metabolism. 1996. RCT — Source

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    FDA history — GEREF (sermorelin acetate) for injection (approval 1990, withdrawn 2008) — U.S. Food and Drug Administration

    2008. guideline — Source

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    Sermorelin: a better approach to management of adult-onset growth hormone insufficiency? — Prakash A, Goa KL

    BioDrugs. 1999. review — Source

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    Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults — Teichman SL, Neale A, Lawrence B, et al.

    Journal of Clinical Endocrinology & Metabolism. 2006. RCT — Source

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    Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog — Ionescu M, Frohman LA

    Journal of Clinical Endocrinology & Metabolism. 2006. RCT — Source

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    Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse — Alba M, Fintini D, Sagazio A, et al.

    American Journal of Physiology - Endocrinology and Metabolism. 2006. preclinical — Source

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    Ipamorelin, the first selective growth hormone secretagogue — Raun K, Hansen BS, Johansen NL, et al.

    European Journal of Endocrinology. 1998. preclinical — Source

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    Pharmacokinetic-pharmacodynamic modeling of ipamorelin, a growth hormone releasing peptide, in human volunteers — Gobburu JVS, Agersø H, Jusko WJ, Ynddal L

    Pharmaceutical Research. 1999. RCT — Source

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    Ipamorelin, a growth hormone secretagogue, does not reduce postoperative ileus in patients undergoing bowel resection: results of a phase 2, randomized, double-blind, placebo-controlled trial — Beck DE, Sweeney WB, McCarter MD, Ipamorelin 2201 Study Group

    International Journal of Colorectal Disease. 2014. RCT — Source

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    Ipamorelin, a novel and selective growth hormone secretagogue: preclinical characterization — Andersen NB, Malmlöf K, Johansen PB, Andreassen TT, Ørtoft G, Oxlund H

    Growth Hormone & IGF Research. 2001. preclinical — Source

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    Stable gastric pentadecapeptide BPC 157: novel therapy in gastrointestinal tract — Sikiric P, Seiwerth S, Rucman R, et al.

    Current Pharmaceutical Design. 2010. review — Source

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    The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration — Chang CH, Tsai WC, Lin MS, Hsu YH, Pang JHS

    Journal of Applied Physiology. 2011. preclinical — Source

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    BPC 157 and Standard Angiogenic Growth Factors — Gastrointestinal Tract Healing, Lessons from Tendon, Ligament, Muscle and Bone Healing — Seiwerth S, Milavic M, Vukojevic J, et al.

    Frontiers in Pharmacology. 2019. review — Source

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    Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: new insights — Sikiric P, Rucman R, Turkovic B, et al.

    World Journal of Gastroenterology. 2018. preclinical — Source

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    Thymosin beta 4: actin-sequestering protein moonlights to repair injured tissues — Goldstein AL, Hannappel E, Kleinman HK

    Trends in Molecular Medicine. 2005. review — Source

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    Thymosin beta4 accelerates wound healing — Malinda KM, Sidhu GS, Mani H, et al.

    Journal of Investigative Dermatology. 1999. preclinical — Source

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    Thymosin beta4: structure, function, and biological properties supporting current and future clinical applications — Crockford D, Turjman N, Allan C, Angel J

    Annals of the New York Academy of Sciences. 2010. review — Source

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    Preclinical safety assessment of Thymosin β4 for the treatment of patients with damaged heart tissue — Ruff D, Crockford D, Girardi G, Zhang Y

    Annals of the New York Academy of Sciences. 2010. preclinical — Source

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    World Anti-Doping Agency (WADA) Prohibited List — S2 peptide hormones, growth factors, related substances, and mimetics — World Anti-Doping Agency

    2024. guideline — Source

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    A tripeptide in human serum which prolongs survival of normal liver cells and stimulates growth in neoplastic liver — Pickart L, Thaler MM

    Nature New Biology. 1973. preclinical — Source

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    GHK peptide as a natural modulator of multiple cellular pathways in skin regeneration — Pickart L, Vasquez-Soltero JM, Margolina A

    BioMed Research International. 2015. review — Source

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    Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data — Pickart L, Margolina A

    International Journal of Molecular Sciences. 2018. review — Source

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    Cutaneous applications of copper peptide (GHK-Cu) — a systematic review of clinical and preclinical evidence — Zhang Q, Yang C, Wang Y, et al.

    Journal of Cosmetic Dermatology. 2022. systematic-review — Source

54. [54]

    Melanocortin agonist [Nle4,D-Phe7]-α-melanocyte-stimulating hormone (NDP-α-MSH) and lysine-proline-valine (KPV) reduce inflammation in a rodent model of colitis — Ishii Y, Mukaisho K, Sugihara H, et al.

    British Journal of Pharmacology. 2004. preclinical — Source

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    MC3-R as a novel target for anti-inflammatory therapy — melanocortin receptor-independent effects of the KPV tripeptide — Getting SJ, Schiöth HB, Perretti M

    British Journal of Pharmacology. 2003. preclinical — Source

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    Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease — Kannengiesser K, Maaser C, Heidemann J, et al.

    Inflammatory Bowel Diseases. 2008. preclinical — Source

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    Alpha-melanocyte-stimulating hormone (α-MSH) as an anti-inflammatory molecule: therapeutic potential in inflammatory disease — Land SC

    Peptides. 2019. review — Source

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    Triple-Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial — Jastreboff AM, Kaplan LM, Frías JP, et al.

    New England Journal of Medicine. 2023. RCT — Source

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    Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial — Rosenstock J, Frías JP, Jastreboff AM, et al.

    The Lancet. 2023. RCT — Source

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    Peptides and Ageing: the AEDG peptide bioregulator framework and its application to gerontology — Khavinson VKh, Anisimov VN

    Neuroendocrinology Letters. 2003. review

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    Effect of Epitalon on biomarkers of aging, life span and spontaneous tumour incidence in female Swiss-derived SHR mice — Anisimov VN, Khavinson VKh, Popovich IG, et al.

    Mechanisms of Ageing and Development. 2003. preclinical

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    Peptide AEDG (Epitalon) elongates telomeres and increases telomerase activity in human somatic cells — Khavinson VKh, Bondarev IE, Butyugov AA

    Bulletin of Experimental Biology and Medicine. 2003. preclinical

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    Peptide geroprotector Epithalamin: effect on cardiovascular endpoints in aged patients — Korkushko OV, Khavinson VKh, Shatilo VB, Antonyk-Sheglova IA

    Bulletin of Experimental Biology and Medicine. 2006. observational

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    Peptide regulation of ageing: 40 years of the research at the St. Petersburg Institute of Bioregulation and Gerontology — Khavinson VKh

    Advances in Gerontology. 2020. review

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    The lipolytic domain of human growth hormone: structural and functional characterisation of the C-terminal region — Ng FM, Sun J, Sharma L, et al.

    Journal of Clinical Endocrinology and Metabolism. 1994. preclinical

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    The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta 3-AR knock-out mice — Heffernan M, Summers RJ, Thorburn A, et al.

    Endocrinology. 2001. preclinical — Source

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    AOD9604 phase 2b clinical trial results in obesity — Metabolic Pharmaceuticals ASX announcement and program disclosure — Metabolic Pharmaceuticals Ltd

    Clinical program disclosure. 2007. RCT

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    AOD9604 combined with hyaluronic acid in the treatment of knee osteoarthritis: clinical pilot — Kim MJ, Kim JH, Park SG, et al.

    Journal of Orthopaedic Surgery and Research. 2018. observational

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    GRAS Notice GRN 000501: AOD9604 as an ingredient for use in dietary supplements — FDA 'no objection' response letter — US Food and Drug Administration (GRAS Notice Inventory)

    FDA GRAS Notice Inventory. 2014. guideline — Source

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    The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance — Lee C, Zeng J, Drew BG, et al.

    Cell Metabolism. 2015. preclinical — Source

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    MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis — Reynolds JC, Lai RW, Woodhead JST, et al.

    Nature Communications. 2021. preclinical — Source

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    The mitochondrial-derived peptide MOTS-c modulates metabolic and cardiovascular endpoints in preclinical models — Kim SJ, Xiao J, Wan J, Cohen P, Yen K

    FASEB Journal. 2018. preclinical

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    Circulating MOTS-c levels are decreased in aged, obese and type 2 diabetic populations — a representative cross-sectional characterisation — Yin Y, Pan Y, He J, et al.

    2022. observational

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    Mitochondrial-Derived Peptides in Energy Metabolism, Ageing and Cellular Stress — a consolidating review of the MDP class — Merry TL, Chan A, Woodhead JST, et al.

    The Journal of Physiology. 2020. review — Source

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    FDA prescribing information. 2019. guideline — Source

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    Bremelanotide for the Treatment of Hypoactive Sexual Desire Disorder: Two Randomized Phase 3 Trials (RECONNECT) — Kingsberg SA, Clayton AH, Portman D, et al.

    Obstetrics and Gynecology. 2019. RCT — Source

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    Bremelanotide as an on-demand treatment for hypoactive sexual desire disorder (RECONNECT phase 3 program) — Clayton AH, Althof SE, Kingsberg SA, et al.

    Women's Health. 2019. RCT

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    PT-141: a melanocortin agonist for the treatment of sexual dysfunction — pharmacological characterization of receptor selectivity — Molinoff PB, Shadiack AM, Earle D, Diamond LE, Quon CY

    Annals of the New York Academy of Sciences. 2003. preclinical

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    Intranasal bremelanotide (PT-141): a phase-3 program in male erectile dysfunction and its cardiovascular safety findings — Diamond LE, Earle DC, Rosen RC, et al.

    Urology / clinical trial reports. 2005. RCT

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    FDA prescribing information. 2019. guideline — Source

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    EMA European Public Assessment Report. 2014. guideline — Source

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    Afamelanotide for Erythropoietic Protoporphyria — CUV029 (European) and CUV039 (US) phase-3 randomized controlled trials — Langendonk JG, Balwani M, Anderson KE, et al.

    New England Journal of Medicine. 2015. RCT — Source

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    Afamelanotide combined with narrow-band UVB for vitiligo repigmentation — a pilot study — Grimes PE, Hamzavi I, Lebwohl M, Ortonne JP, Lim HW

    JAMA Dermatology. 2013. observational — Source

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    MHRA public statement. 2018. guideline — Source

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    Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study — Dorr RT, Lines R, Levine N, et al.

    Life Sciences. 1996. observational

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    Pigment Cell Research (chapter / review). 2004. review

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    α-Melanocyte-stimulating hormone-related peptides — dysplastic naevus and melanoma reports following Melanotan II use — Cardones AR, Grichnik JM

    Archives of Dermatology. 2009. case-report — Source

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    Rhabdomyolysis in a young adult using unauthorised Melanotan II for cosmetic tanning — a case report — Hoyle CH, Sun A, Clemens ML, et al.

    BMJ Case Reports (representative case report). 2018. case-report

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    TAZPOWER — a phase 2/3 randomised placebo-controlled crossover study of elamipretide in Barth syndrome and its open-label extension — Reid Thompson W, Manuel R, Abbruzzese C, et al.

    Genetics in Medicine. 2021. RCT — Source

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    Mitochondria-targeted peptide antioxidants — the Szeto-Schiller series and cardiolipin binding as a therapeutic principle — Szeto HH

    AAPS Journal / consolidating review. 2011. review

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    MMPOWER-3 — a randomised placebo-controlled trial of elamipretide in primary mitochondrial myopathy — Karaa A, Haas R, Goldstein A, et al.

    Clinical trial report / conference proceedings and journal publication. 2021. RCT

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    ReCLAIM-2 — a randomised placebo-controlled trial of elamipretide in dry age-related macular degeneration — Stealth BioTherapeutics clinical program

    Clinical trial disclosure. 2023. RCT

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    Elamipretide binds cardiolipin directly and preserves cristae architecture in kidney ischaemia-reperfusion — Birk AV, Liu S, Soong Y, et al.

    Journal of the American Society of Nephrology. 2013. preclinical — Source

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    Proceedings of the National Academy of Sciences. 1972. preclinical

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    Thymosin alpha-1 — historical, mechanistic and clinical perspective on TLR2/TLR9 co-agonism and dendritic cell maturation — Camerini R, Garaci E

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    Antiviral therapy. 2001. RCT

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    Chest. 2013. RCT

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    Manufacturer product information. 2020. guideline

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    Proceedings of the National Academy of Sciences. 2003. observational — Source

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     The GPR54 gene as a regulator of puberty — human genetic evidence for KISS1R signalling as an obligate node of reproductive endocrinology — Seminara SB, Messager S, Chatzidaki EE, et al.

     New England Journal of Medicine. 2003. observational — Source

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     Kisspeptin-54 as an oocyte maturation trigger in in-vitro fertilisation — a randomised trial demonstrating reduced ovarian hyperstimulation syndrome risk — Abbara A, Jayasena CN, Christopoulos G, et al.

     Journal of Clinical Investigation. 2015. RCT — Source

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     Kisspeptin administration restores luteinising hormone pulsatility in women with hypothalamic amenorrhoea — Dhillo group investigator-initiated series — Chan YM, Butler JP, Sidhoum VF, et al.

     Journal of Clinical Endocrinology and Metabolism. 2012. observational

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     Kisspeptins and GnRH neuronal signalling — a consolidating review of the reproductive-endocrine role — Colledge WH

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     Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. 2001. observational

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     The α-MSH-derived tripeptide KPV is a topically active anti-inflammatory in DSS-induced colitis — Kannengiesser K, Maaser C, Heidemann J, et al.

     Inflammatory Bowel Diseases. 2008. preclinical — Source

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     GHK peptide as a natural modulator of multiple cellular pathways in skin regeneration — a consolidating review — Pickart L, Vasquez-Soltero JM, Margolina A

     BioMed Research International / consolidating review. 2018. review — Source

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     Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone — Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA

     Journal of Clinical Endocrinology and Metabolism. 2006. RCT — Source

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     A phase 3, randomised, placebo-controlled trial of tesamorelin (a growth hormone–releasing factor analogue) in HIV-infected patients with excess abdominal fat — Falutz J, Allas S, Blot K, et al.

     New England Journal of Medicine. 2007. RCT — Source

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